1. What is the limit to the size of an avascular microtumour
2. What does Avastin bind to and what is its real name
3. What inhibitor of metastatic growth is produced by the primary tumour, how is this produced from plasminogen
4. How many somatic mutations are there in a typical cancer cell, how many mutated genes in each
5. What are the 6 hallmarks of cancer which are intrinsic
6. What are the 3 extrinsic hallmarks
7. What is Warburg metabolism
8. What are secreted by endothelial cells in response to VEGF, what do each of these do
9. Why is a necrotic core often formed
10. How many DNA mutations are there each day in each cell and how many of these are not repaired
11. Which genes are mutated in HNPCC
12. What is gene amplification
13. What translocations cause Burkitt’s lymphoma
14. What are the two lymphoma divisions
15. What is MYC
16. What is a papilloma
17. What is src
18. How are phorbol esters carcinogens but not mutagens
19. How does methylation in tumour cells differ from normal both generally and on tumour suppressors